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July 16, 2025Frontiers in OncologyOpen Access

M6A RNA modification: focusing on non-small cell lung cancer progression, therapeutic strategies and challenges

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Authors

YYYuyang YanJYJun‐Jie YinQDQuan Ding

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Overview

This review highlights m6A's role in NSCLC progression and its potential as a diagnostic biomarker, suggesting new therapeutic strategies to overcome challenges.

Key Points

  • M6A modification significantly impacts tumor proliferation, apoptosis, and metastasis in non-small cell lung cancer.
  • The regulatory networks of m6A influence metabolic reprogramming, including glycolysis and ferroptosis in lung cancer.
  • Challenges in translating m6A-targeted therapies into clinical practice include detection method standardization and regulatory complexity.
  • Future research should leverage multi-omics to enhance our understanding of m6A and its potential in precision oncology.

Cite This Study

Yan et al. (2025) studied this question.

synapsesocial.com/papers/689a02c3e6551bb0af8ccb84https://doi.org/10.3389/fonc.2025.1622359
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1m6A RNA Modification: Technologies Behind Future Anti-Cancer Therapy2025 · 2 citations
  2. 2The m6A modification in cancer: roles, implications, and its potential in therapy2025 · 12 citations
  3. 3Role of N6-methyladenosine in the progression, treatment regulation, and prognosis prediction of lung cancer2026
  4. 4The lncRNA-m6A axis in cancer: a bidirectional regulatory network in tumor progression and therapeutic resistance2026
  5. 5Emerging functions of m6A-modified circRNAs and their targeting strategies in lung cancer2026 · 2 citations