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July 6, 2026Scientific ReportsOpen Access

Gut barrier integrity biomarkers are associated with increased inflammation and predict disease status in hospitalized COVID-19 patients

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Authors

CBChristopher M. BastingTSTy SchroederKFKathie G. Ferbas

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Overview

Randomized trial investigates biomarkers for inflammation in hospitalized COVID-19 patients, suggesting their use in assessing disease severity.

Key Points

  • This research aims to analyze gut barrier integrity biomarkers and their relationship with inflammation in COVID-19 patients.
  • Investigated plasma biomarkers for intestinal permeability and cytokines in hospitalized COVID-19 patients versus healthy volunteers.
  • Conducted correlation analyses and employed a random forest model to evaluate discriminative accuracy of biomarkers.
  • Hospitalized COVID-19 patients showed increased levels of pro-inflammatory cytokines and microbial translocation markers compared to healthy volunteers.
  • Significant alterations in relationships between biomarkers, particularly IL-17A and IL-23, were noted.
  • IL-6 and LBP emerged as key biomarkers for prediction accuracy in assessing disease severity.

Cite This Study

Basting et al. (2026) studied this question.

synapsesocial.com/papers/6a4b453d997070ff83b5b1a2https://doi.org/10.1038/s41598-026-59934-5
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Also Consider

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  1. 1Correlations Between Gut Microbiome Changes, Gut Barrier Function, and Immune Homeostasis in COVID-19 Patients: The Role of Gut Microbiota in Immunity and Cancer Prevention2025
  2. 2SARS-CoV-2 infection is associated with intestinal permeability, systemic inflammation, and microbial dysbiosis in hospitalized patients2024 · 17 citations
  3. 3Longitudinal multi-omic dynamics in hospitalized COVID-19 patients based on disease severity2026
  4. 4Gut microbiome dysbiosis and inflammatory markers in severe COVID-19: links to atherosclerosis and potential therapeutic insights.2025
  5. 5Prognostic Prediction in COVID-19 Patients: A Comprehensive Analysis of Gut Microbiota and Hematological Biomarkers2026