Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 6, 2026American Journal of HematologyOpen Access

Undetectable Hydroxyurea Levels in the Majority of Sickle Cell Disease Patients, Especially in Young Children

View Full Paper
Ask AI
Bookmark
Share

Authors

SVSigrid van der VeenUtrecht UniversityBBBart J. BiemondAmsterdam University Medical CentersMCMarjon H. CnossenErasmus MC

Discussion

Loading...

Member takes

Implication

Randomized trial examines HU levels and treatment response in SCD patients, suggesting suboptimal treatment especially for children.

Key Points

  • To assess hydroxyurea levels and treatment responses in sickle cell disease patients.
  • Measured hydroxyurea levels in whole blood of 955 SCD patients using mass spectrometry.
  • Defined detection as Z-score > 2.5 relative to healthy controls.
  • Analyzed data from patients with homozygous sickle cell disease not receiving recent transfusions.
  • Detected hydroxyurea in 39% of patients ≥ 10 years (143/369) and 24% of patients < 10 years (23/109).
  • Low MCV and HbF observed in undetected hydroxyurea levels, indicating suboptimal treatment.
  • Neutropenia occurred in 8.0% of patients with detectable HU versus 4.5% with undetectable HU.

Cite This Study

Veen et al. (2026) studied this question.

synapsesocial.com/papers/6a4b45b2997070ff83b5b49fhttps://doi.org/10.1002/ajh.70429
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Systematic literature review on hydroxyurea treatment of SCD in low- to middle-income countries2026
  2. 2Real-world effectiveness and safety of hydroxyurea in adults with hemoglobin SC disease: A retrospective cohort study in Quebec, Canada2025
  3. 3Iron deficiency limits hydroxyurea-induced fetal hemoglobin and clinical efficacy in sickle cell disease2025
  4. 4Evaluation of hydroxyurea effect in patients with sickle cell disease: A prospective observational study2026
  5. 5Hydroxyurea (hydroxycarbamide) use in adults with haemoglobin SC disease: A real‐world study in Quebec2026