Key result
In male patients with chronic kidney disease, increased left ventricular end-diastolic volume index was associated with a higher risk of 1-year cardiac events (RR 4.615).
Why the study?
CKD causes myocardial tissue alterations linked to cardiac events and mortality, and cardiac MRI may noninvasively detect these abnormalities and their relationship with prognosis.
Do myocardial T1 and T2 values and cardiac functional parameters measured by cardiac MRI predict 1-year cardiac outcomes in male patients with chronic kidney disease?
Observational (n=38)
No
Do myocardial T1 and T2 values and cardiac functional parameters measured by cardiac MRI predict 1-year cardiac outcomes in male patients with chronic kidney disease?
Relative Risk: 4.615 (95% CI 0.762–27.964)
p-value: p=0.048
Cardiac MRI-derived LVEDV and LVEDVI, along with T1/T2 mapping, may help identify male CKD patients at risk for adverse cardiac events at 1 year.
LVEDV and LVEDVI thresholds were associated with 1-year events in male CKD; hypothesis-generating for MRI risk stratification pending validation.
Background: Chronic kidney disease (CKD) leads to myocardial tissue alterations that are associated with cardiac events and mortality. Cardiac magnetic resonance imaging (MRI) may be useful for noninvasively detectingmyocardial abnormalities associated with CKD and its relationship with patients’ prognoses.Objectives: The aim of this study was to evaluate the relationship between myocardial T1 and T2 values, cardiacfunction and 1-year outcomes in male patients with CKD.Methods: Thirty-eight patients with CKD were examined using a 1.5T imager. The relationship between thepatients’ native T1 or T2 values and their age, renal function, cardiac functional parameters measured by cardiacMRI, and 1-year outcomes was assessed. The 1-year outcomes was defined as cardiac events including hospitalization or death associated with coronary artery diseases or heart failure that occurred within 1 year after having acardiac MRI.Results: Native T1 and T2 values of the myocardium were significantly higher than those of our institutional reference standard (P < 0.05 for both). The patients’ T1 values were correlated with several cardiac functionalparameters (P < 0.05). There were significant differences in the left ventricular end-diastolic volume (LVEDV) aswell as the LVEDV index (LVEDVI) between patients with and without cardiac events within 1 year after havinga cardiac MRI (P = 0.048 for both). A receiver operating characteristic analysis revealed that a LVEDV of 124 mLand a LVEDVI of 75.05 mL/m2 were appropriate thresholds for identifying patients with CKD with poor 1-yearoutcomes.Conclusions: T1T2 mapping might be a useful tool to quantify myocardial tissue alterations specific for CKD andits cardiac function. LVEDV and LVEDVI are significantly related to 1-year outcomes in male patients with CKD.
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Omori et al. (2022) conducted an observational in Chronic kidney disease (n=38). Increased left ventricular end-diastolic volume index (LVEDVI) vs. Lower LVEDVI was evaluated on 1-year cardiac events (hospitalization or death for coronary artery diseases or heart failure) (RR 4.615, 95% CI 0.762-27.964, p=0.048). In male patients with chronic kidney disease, increased left ventricular end-diastolic volume index was associated with a higher risk of 1-year cardiac events (RR 4.615).
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