Key result
Native T1 was raised in all hypertrophic conditions, while markedly raised native T2 was specific to chronic kidney disease compared to other groups (p < 0.001), suggesting intramyocardial fluid.
Why the study?
Native T1 is a non-specific readout that may relate to increased intramyocardial fluid as well as diffuse fibrosis, prompting examination of concomitant T1 and T2 mapping signatures across hypertrophic conditions.
Can native T1 and T2 mapping by CMR differentiate between hypertrophic cardiac conditions (CKD, HTN, HCM)?
Population
154 CKD patients, 163 HTN patients, 158 HCM patients, and 133 normotensive controls
Comparison
CKD vs HTN vs HCM vs normotensive controls
Design
Prospective multicentre study
Authors
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Native T2 may differentiate CKD hypertrophy; leaves open intramyocardial fluid role pending validation.
Observational (n=608)
Yes
Can native T1 and T2 mapping by CMR differentiate between hypertrophic cardiac conditions (CKD, HTN, HCM)?
p-value: p=<0.001
Native T1 and T2 mapping provide distinct CMR signatures for hypertrophic conditions, with markedly raised native T2 being specific to CKD, suggesting intramyocardial fluid accumulation.
Arcari et al. (2020) conducted an observational in Hypertrophic cardiac conditions (CKD, HTN, HCM) (n=608). Chronic kidney disease vs. Hypertensive cardiomyopathy, hypertrophic cardiomyopathy, and normotensive controls was evaluated on Native T1 and T2 mapping values (p=<0.001). Native T1 was raised in all hypertrophic conditions, while markedly raised native T2 was specific to chronic kidney disease compared to other groups (p < 0.001), suggesting intramyocardial fluid.
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