Why the study?
Can T1 and T2 mapping on cardiac MRI characterize cardiac involvement in patients with uremic cardiomyopathy?
Can T1 and T2 mapping on cardiac MRI characterize cardiac involvement in patients with uremic cardiomyopathy?
T1 and T2 mapping on cardiac MRI provide valuable non-invasive characterization of interstitial fibrosis and myocardial edema in patients with uremic cardiomyopathy.
May support non-invasive CMR characterization in uremic cardiomyopathy; leaves open prospective validation before clinical adoption.
Uremic cardiomyopathy (UC) is the cardiac remodelling that occurs in patients with chronic kidney disease (CKD). It is characterised by a left ventricular (LV) hypertrophy phenotype, diastolic dysfunction and generally preserved LV ejection fraction. UC has a major role mediating the increased rate of cardiovascular events, especially heart failure related, observed in patients with CKD. Recently, the use of T₁ and T₂ mapping techniques on cardiac MRI has expanded the ability to characterise cardiac involvement in CKD. Native T₁ mapping effectively tracks the progression of interstitial fibrosis in UC, whereas T₂ mapping analysis suggests the contribution of myocardial oedema, at least in a subgroup of patients. Both T₁ and T₂ increased values were related to worsening clinical status, myocardial injury and B-type natriuretic peptide release. Studies investigating the prognostic relevance and histology validation of mapping techniques in CKD are awaited.
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Arcari et al. (2022) studied this question.
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