Key result
In healthy individuals, median ultra-highly sensitive cardiac troponin I concentrations were significantly lower in women (0.43 ng/L) compared to men (0.83 ng/L).
Why the study?
Assays enabling ultra-highly sensitive quantification of cTnI allow accurate measurement in healthy subjects, but the distribution and relations to sex and age required evaluation.
Comparison
Quanterix u-hs-cTnI immunoassay vs Abbott ARCHITECT STAT High Sensitivity Troponin I assay
Design
Cohort assay validation and cross-sectional distribution study
Authors
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May inform sex-specific u-hs-cTnI cutoffs; leaves open prospective outcome validation before clinical use.
Observational (n=400)
Yes
Absolute Event Rate: 0.43% vs 0.83%
p-value: p=<0.001
An ultra-highly sensitive cTnI assay can quantify troponin in 95% of healthy individuals, revealing significantly lower 99th percentiles in women compared to men.
Mastali et al. (2022) conducted an observational in Healthy individuals (n=400). Female sex vs. Male sex was evaluated on Median ultra-highly sensitive cardiac troponin I (u-hs-cTnI) concentration (p=<0.001). In healthy individuals, median ultra-highly sensitive cardiac troponin I concentrations were significantly lower in women (0.43 ng/L) compared to men (0.83 ng/L).
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