October 18, 2017Clinical Chemistry
Comprehensive Age and Sex 99th Percentiles for a High-Sensitivity Cardiac Troponin I Assay
Key result
A retrospective analysis of 132,417 patients was conducted to establish age- and sex-specific 99th percentiles for the SMC cTnI test, which previously used a uniform 99th percentile of 7.1 ng/L.
Population
132,417 all-comer community-based patients at risk for cardiovascular disease whose physicians ordered the…
Design
Cross-sectional
Authors
Discussion
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Implication
Age- and sex-specific 99th percentiles for SMC cTnI may refine AMI diagnosis in select patients; leaves open whether adoption improves outcomes.
Structured PICO
P
Population
132,417 community-based patients at risk for cardiovascular disease who had the SMC cTnI test ordered between 2013 and 2014.
E
Exposure
Single Molecule Counting (SMC) cTnI test (Singulex)
O
Outcome
Establishment of the 99th percentile for the SMC cTnI test based on age and sexsurrogate
This study aimed to establish age- and sex-specific 99th percentiles for a high-sensitivity cardiac troponin I assay using a large community-based cohort.
Limitations
- SMC cTnI is a laboratory-developed test (not cleared by the Food and Drug Administration).
Cite This Study
Estis et al. (2017) conducted a letter in At risk for cardiovascular disease (n=132,417). Single Molecule Counting (SMC) cTnI test was evaluated on 99th percentile for the SMC cTnI test. A retrospective analysis of 132,417 patients was conducted to establish age- and sex-specific 99th percentiles for the SMC cTnI test, which previously used a uniform 99th percentile of 7.1 ng/L.