Key result
The overall 99th percentile for high sensitivity cardiac troponin I measured by Single Molecule Counting technology in healthy blood donors was 5 ng/L, with only minor differences between sexes.
Why the study?
Knowledge of high sensitivity cardiac troponin I distribution in a reference population is required for its clinical use, prompting definition of the Upper Reference Limit using Single Molecule Counting technology.
Population
1140 blood donors selected by medical history and biomarkers
Design
Cross-sectional reference population study
Authors
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Provides a candidate 99th percentile for hs-cTnI by SMC; hypothesis-generating for MI thresholds pending prospective validation.
Cross-Sectional (n=1,140)
No
Establishing the 99th percentile of hs-cTnI at 5 ng/L using SMC technology provides a critical reference threshold for diagnosing myocardial infarction in clinical practice.
Agnello et al. (2019) conducted a cross-sectional in Healthy blood donors (n=1,140). High sensitivity cardiac troponin I (hs-cTnI) measurement was evaluated on 99th percentile of hs-cTnI distribution (95% CI 4.2-5.6). The overall 99th percentile for high sensitivity cardiac troponin I measured by Single Molecule Counting technology in healthy blood donors was 5 ng/L, with only minor differences between sexes.
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