Key result
Coronary-artery bypass grafting is a better approach than percutaneous coronary intervention for severe left anterior descending artery and multiple-vessel disease in children with Kawasaki disease.
Why the study?
Because coronary lesions caused by Kawasaki disease differ significantly from adult atherosclerotic disease, determining the optimal timing and selection of revascularization procedures remains challenging.
What is the optimal coronary revascularization strategy for patients with coronary-artery obstructive lesions due to Kawasaki disease?
What is the optimal coronary revascularization strategy for patients with coronary-artery obstructive lesions due to Kawasaki disease?
CABG is the preferred revascularization strategy over PCI for severe coronary artery obstructive lesions in children and adolescents with Kawasaki disease due to anatomical limitations like small vessel size and calcification.
CABG may be preferred for severe multivessel KD lesions in children; leaves open need for comparative trials.
As an acquired ischemic heart disease in childhood, coronary-artery disease caused by Kawasaki disease (KD) has been known worldwide since the mid-1970s. KD patients who develop coronary-artery obstructive disease often need revascularization some time in their life. Coronary-artery revascularization for KD coronary lesions can be done with the surgical coronary-artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) procedures. However, the characteristics of coronary-arterial lesions caused by KD significantly differ from atherosclerotic coronary disease in adults. Therefore, it is much more difficult to determine the optimal time and selection of a coronary-artery revascularization procedure for KD sequelae. CABG using the internal thoracic artery has been accepted as a very useful and beneficial procedure since the mid-1980s, even in small children. Although the use of PCI in the late period can be effective in some adolescent and adult patients, the small vessel size and severe coronary-artery calcification are often limiting factors for its use in children. Therefore, CABG is a better approach for severe leftanterior descending artery and multiple-vessel disease in children and adolescents with KD coronary sequelae. Good coronary revascularization can improve the long-term outcomes of patients with severe KD complications.
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Kitamura et al. (2019) conducted a review in Kawasaki disease with coronary-artery obstructive lesions. Coronary-artery bypass grafting (CABG) vs. Percutaneous coronary intervention (PCI) was evaluated. Coronary-artery bypass grafting is a better approach than percutaneous coronary intervention for severe left anterior descending artery and multiple-vessel disease in children with Kawasaki disease.
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