Key result
Internal thoracic artery grafts demonstrated better long-term patency rates compared to other grafts in patients with Kawasaki disease (HR 0.33; 95% CI 0.17-0.66).
Why the study?
Coronary artery bypass grafting is performed for coronary inflammation and aneurysms in Kawasaki disease, but it remained unclear which CABG strategy provides better graft patency and early and long-term outcomes.
Do arterial conduits improve graft patency and reduce long-term mortality compared to venous conduits in patients undergoing CABG for Kawasaki disease?
Population
1,191 patients undergoing CABG for Kawasaki disease across 32 studies
Comparison
Different graft conduits (ITAs vs SV vs other arteries) and CABG strategies (arterial vs venous vs mixed)
Design
Systematic review and Bayesian random-effects network meta-analysis
Authors
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Arterial conduits may be preferred in KD CABG; extends observational data on conduit selection for patency and survival.
Meta-Analysis (n=1,191)
Do arterial conduits improve graft patency and reduce long-term mortality compared to venous conduits in patients undergoing CABG for Kawasaki disease?
Hazard Ratio: 0.33 (95% CI 0.17–0.66)
In patients undergoing CABG for Kawasaki disease, the use of arterial conduits provides superior long-term graft patency and lower mortality compared to venous grafts.
Salsano et al. (2021) conducted a meta-analysis in Kawasaki disease (n=1,191). Internal thoracic artery grafts vs. Saphenous vein and other arterial grafts was evaluated on Graft patency at long-term follow-up (HR 0.33, 95% CI 0.17-0.66). Internal thoracic artery grafts demonstrated better long-term patency rates compared to other grafts in patients with Kawasaki disease (HR 0.33; 95% CI 0.17-0.66).
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