Key result
Echo-guided papillary muscle repositioning using an external device reduced papillary muscle tethering distance from 31.1 mm to 26.8 mm (P<0.01) and resolved moderate ischemic mitral regurgitation.
Why the study?
Does echo-guided papillary muscle repositioning using an external device reduce ischemic mitral regurgitation without compromising left ventricular function in a sheep model of ischemic MR?
Does echo-guided papillary muscle repositioning using an external device reduce ischemic mitral regurgitation without compromising left ventricular function in a sheep model of ischemic MR?
Absolute Event Rate: 26.8% vs 31.1%
p-value: p=<0.01
An external device that repositions papillary muscles can reduce ischemic mitral regurgitation without compromising LV function in a preclinical model.
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Resolves moderate ischemic MR in sheep without impairing LV function; leaves open translation to human therapy.
Hung et al. (2002) studied Ischemic mitral regurgitation (n=10). Echo-guided papillary muscle repositioning using an external device vs. Baseline (after MI) was evaluated on Papillary muscle tethering distance (p=<0.01). Echo-guided papillary muscle repositioning using an external device reduced papillary muscle tethering distance from 31.1 mm to 26.8 mm (P<0.01) and resolved moderate ischemic mitral regurgitation.