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April 26, 2005Circulation

Percutaneous Mitral Valve Repair for Chronic Ischemic Mitral Regurgitation

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Why the study?

Does percutaneous coronary sinus-based mitral annuloplasty reduce chronic ischemic mitral regurgitation and improve mitral annular geometry in an ovine model?

Population

6 sheep with chronic ischemic mitral regurgitation developed 8 weeks after induced posterior myocardial…

Design

Preclinical

Authors

MDMasao DaimonTSTakahiro ShiotaAGA. Marc Gillinov

Discussion

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Overview

Hypothesis-generating in ovine ischemic MR; leaves open safety and efficacy of percutaneous annuloplasty in patients.

Structured PICO

Does percutaneous coronary sinus-based mitral annuloplasty reduce chronic ischemic mitral regurgitation and improve mitral annular geometry in an ovine model?

P
Population
6 sheep with chronic ischemic mitral regurgitation (IMR) developed 8 weeks after induced posterior myocardial infarction
I
Intervention
Percutaneous transvenous catheter-based mitral valve repair using a novel annuloplasty device placed in the coronary sinus
O
Outcome
Mitral regurgitation (MR) jet area, mitral annular anterior-posterior (A-P) dimension, and mitral valve tenting area (MVTa)surrogate

Percutaneous coronary sinus-based mitral annuloplasty effectively reduces chronic ischemic mitral regurgitation and improves annular geometry in an ovine model, suggesting potential for clinical application.

Cite This Study

Daimon et al. (2005) studied this question.

synapsesocial.com/papers/6a7d275f76c74e41c946ceachttps://doi.org/10.1161/01.cir.0000163547.03188.ac
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