Key result
Elevated left atrial pressure from bicuculline-induced seizures produced identical alterations in pulmonary fluid and protein flux as mechanical left atrial balloon inflation in sheep.
Pressor effects alone explain lymph changes in sheep; leaves open neural contributions to human neurogenic pulmonary edema.
We compared the effects of elevated left atrial pressure of central nervous system origin (bicuculline-induced seizures) with an identical pulmonary vascular pressure elevation induced in six sheep by inflation of a balloon in the left atrium. The degree and duration of the consequent elevation in pulmonary lymph flow and the alteration in protein movement in the two groups was identical. Alterations in pulmonary fluid and protein flux resulting from generalized seizures can be explained by the pressor response alone; specific brain-lung neural interactions need not be postulated.
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Simon et al. (1982) studied Elevated left atrial pressure (n=6). Elevated left atrial pressure of CNS origin (bicuculline-induced seizures) vs. Pulmonary vascular pressure elevation induced by inflation of a balloon in the left atrium was evaluated on Degree and duration of elevation in pulmonary lymph flow and alteration in protein movement. Elevated left atrial pressure from bicuculline-induced seizures produced identical alterations in pulmonary fluid and protein flux as mechanical left atrial balloon inflation in sheep.
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