Key result
Insulin resistance and related metabolic abnormalities drive increased cardiovascular risk in type 2 diabetes.
Type 2 diabetes mellitus is associated with a marked increase in the risk of atherosclerotic diseases, including coronary heart disease, peripheral arterial disease, and cerebrovascular disease. Insulin resistance is a key factor in the pathogenesis of type 2 diabetes mellitus. Insulin resistance and its attendant metabolic abnormalities may cause much of the increased cardiovascular risk of type 2 diabetes mellitus. Among the abnormalities associated with insulin resistance are dyslipidemia, hypertension, systemic inflammation, and a prothrombotic state. This review discusses the role that each of these disorders plays in the cardiovascular risk of type 2 diabetes mellitus.
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Watson et al. (2003) conducted a review in Type 2 diabetes mellitus and atherosclerosis. Insulin resistance was evaluated. Insulin resistance and its associated metabolic abnormalities, including dyslipidemia and hypertension, play a key role in the increased cardiovascular risk of type 2 diabetes mellitus.
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