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July 7, 2026Communications MedicineOpen Access

Rostral lesion shift and tract-specific degeneration drive functional heterogeneity in degenerative cervical myelopathy

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Authors

FMFauziyya MuhammadDPDario PfyfferNDNicholas Dobson

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Overview

Randomized trial maps spinal cord damage in patients with cervical myelopathy, suggesting personalized treatment strategies.

Key Points

  • To explore the relationship between intramedullary lesion mapping and functional outcomes in degenerative cervical myelopathy.
  • Applied automated deep-learning segmentation to analyze spinal cord lesions in 73 patients with DCM.
  • Utilized multiple functional assessments including modified Japanese Orthopaedic Association score, Nine-Hole Peg Test, and Standing Balance Test.
  • Conducted multivariate modeling to determine predictors of balance and dexterity impairments.
  • T2-hyperintense lesions observed in 45% of patients, correlating with increased neurological disability.
  • Liason density peaked at C4, indicating a rostral lesion shift affecting pathways.
  • Balance impairment predicted by damage to dorsal columns (P = 0.032) and lateral reticulospinal tract (P = 0.011), with preserved tissue aiding balance only when key pathways remained intact.

Cite This Study

Muhammad et al. (2026) studied this question.

synapsesocial.com/papers/6a4c9687331bc25c9e5f3f5ahttps://doi.org/10.1038/s43856-026-01764-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intramedullary Lesions and Perilesional Tissue Bridges Predict Motor Recovery in Degenerative Cervical Myelopathy: A Multicenter Study2025
  2. 2245 Linking Cervical Spinal Cord White Matter Magnetization Transfer Ratio to NIH Toolbox Based Analyses of Motor Function in Degenerative Cervical Myelopathy2024
  3. 3E.4 Machine learning based patient classification to predict neurological deterioration in mild Degenerative Cervical Myelopathy2024
  4. 4Advanced MRI metrics improve the prediction of baseline disease severity for individuals with degenerative cervical myelopathy2024 · 8 citations
  5. 5Spinal cord diffusion tensor imaging predicts balance in degenerative cervical myelopathy2026