Key result
Artificially calcified porcine aortic tissues had a higher compressive E-modulus (227±34 kPa vs 147±15 kPa, p<0.01) and lower tensile strength and tearing resistance than healthy tissues.
Why the study?
Can in vitro biomechanical tests (compression, tensile, tearing) distinguish between healthy and calcified porcine aortic tissues?
Can in vitro biomechanical tests (compression, tensile, tearing) distinguish between healthy and calcified porcine aortic tissues?
Absolute Event Rate: 227% vs 147%
p-value: p=<0.01
In vitro biomechanical testing demonstrates that artificially calcified porcine aortic tissues have higher compressive stiffness but lower tensile strength and tearing resistance compared to healthy tissues.
Validated in vitro compression testing for aortic calcification; leaves open prospective validation for clinical anastomosis assessment.
An anastomosis performed in calcified tissues tears up faster than in healthy tissues. This study develops and validates an in vitro non-destructive method to distinguish healthy from calcified aortic tissues. An uniaxial unconfined compression test is able to distinguish healthy from calcified aortas (p<0.01). The compressive E-modulus at a strain level of 10% is 227+/-34kPa for artificially calcified and 147+/-15kPa for healthy porcine aortic tissues. Calcified aortic tissues have a lower tensile strength than healthy porcine aortic tissues (p<0.05). The ultimate tensile strength is 1.34+/-0.18MPa and 1.55+/-0.31MPa for artificially calcified and healthy porcine aortic tissues respectively. Calcified aortic tissues have a lower resistance to tearing than healthy aortic tissues (p<0.05). The resistance to tearing is 1.78+/-0.33N/mm and 2.16+/-0.64N/mm for artificially calcified and healthy porcine aortic tissues respectively.
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Walraevens et al. (2008) studied Calcified aortic tissues. Artificially calcified porcine aortic tissues vs. Healthy porcine aortic tissues was evaluated on Compressive E-modulus at a strain level of 10% (p=<0.01). Artificially calcified porcine aortic tissues had a higher compressive E-modulus (227±34 kPa vs 147±15 kPa, p<0.01) and lower tensile strength and tearing resistance than healthy tissues.
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