Key result
Unilateral stimulation of carotid chemoreceptors in cats resulted in parallel actions, including inhibition of rostral VRG I-Driver neurones and concurrent excitation of premotor VRG neurones.
Population
15 anaesthetized, bilaterally vagotomized, paralysed, artificially ventilated cats
Design
Preclinical
Authors
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Cat data extend VRG integration models; leaves open human ventilatory translation.
Carotid chemoreceptor stimulation in cats demonstrates parallel processing of input to brainstem neurones, simultaneously controlling inspiratory phase timing and motor output amplitude.
Morris et al. (1996) studied this question. Carotid chemoreceptor stimulation (CO2-saturated saline solution) was evaluated on Firing rate changes in NTS and VRG neurones. Unilateral stimulation of carotid chemoreceptors in cats resulted in parallel actions, including inhibition of rostral VRG I-Driver neurones and concurrent excitation of premotor VRG neurones.
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