Key result
This review summarizes current knowledge on bicuspid aortic valve, emphasizing the need for a unified nosology and long-term prospective studies to understand BAV-associated valvulo-aortopathy.
Why the study?
BAV displays marked clinical heterogeneity and recent consensus on a unified nosology highlights the need to address unresolved issues and guide prospective studies.
This review highlights the clinical heterogeneity of bicuspid aortic valve, the importance of a unified nosology, and the need for long-term prospective studies to better understand BAV-associated valvulo-aortopathy.
Bicuspid aortic valve (BAV), a common congenital anomaly with various morphological phenotypes, is also characterised by marked heterogeneity in clinical presentations including clinically silent condition with mild valvulo-aortopathy, progressive valvulopathy and complex valvulo-aortopathy with shorter life expectancy. The clinical importance of using a general and unified nosology for BAV is well-accepted by opinion leaders and an international consensus statement has been recently published, which will serve as an important scientific platform for BAV. This review describes the current knowledge of BAV based on clinical studies, addresses several unresolved issues requiring investigators' attention and highlights the necessity of prospective studies with a very long follow-up duration for better appreciation of BAV-associated valvulo-aortopathy. In addition, the progression of valvular calcification in patients with BAV and its potential contribution to development of valvulopathy will be discussed.
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Sun et al. (2022) conducted a review in Bicuspid aortic valve. This review summarizes current knowledge on bicuspid aortic valve, emphasizing the need for a unified nosology and long-term prospective studies to understand BAV-associated valvulo-aortopathy.
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