Key result
Recent studies indicate bicuspid aortic valve-associated aortopathy has a heterogeneous spectrum, with valvular insufficiency potentially posing a greater risk for aortic events than stenosis.
BAV-associated aortopathy presents with distinct phenotypes, and patients with valvular insufficiency may require more tailored surgical strategies due to higher risk of aortic events.
May inform phenotype-based surveillance in BAV aortopathy; leaves open prospective validation of insufficiency-specific thresholds.
PURPOSE OF REVIEW: This focused review summarizes key insights from the past 12 months of basic science and clinical research on bicuspid aortic valve (BAV)-associated aortopathy. RECENT FINDINGS: Recent studies in BAV-associated aortopathy support a heterogeneous spectrum of disease with distinct phenotypes. Basic science studies provide further support for the concept of regional differences in the severity of aortopathy within the aorta of BAV patients. Clinical studies compared outcomes of BAV patients after isolated aortic valve replacement and showed that those with primarily valvular insufficiency as compared with stenosis may be at greater risk for important aortic events over time. These novel insights will be important to optimize future aortic resection strategies and clinical practice guidelines. SUMMARY: As the most common congenital heart defect, BAV disease is a considerable health burden. Recent studies show differences in the clinical manifestation of disease patterns that may have important implications for future research and the evolution toward more patient-specific surgical practice guidelines.
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Guzzardi et al. (2016) conducted a review in Bicuspid aortic valve (BAV)-associated aortopathy. Recent studies indicate bicuspid aortic valve-associated aortopathy has a heterogeneous spectrum, with valvular insufficiency potentially posing a greater risk for aortic events than stenosis.
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