Key result
Natriuretic peptides are clinically effective for evaluating suspected and confirmed heart failure, though their diagnostic value is limited in renal dysfunction and other non-heart failure conditions.
Why the study?
What is the clinical role and diagnostic value of natriuretic peptides in patients with heart failure and other conditions?
What is the clinical role and diagnostic value of natriuretic peptides in patients with heart failure and other conditions?
Natriuretic peptides are important biomarkers for diagnosing and managing heart failure, though their diagnostic value is limited in conditions like renal dysfunction where levels may be elevated without heart failure.
Supports caution interpreting natriuretic peptides in renal dysfunction; leaves open refined thresholds for non-HF conditions.
A clinical role of biomarkers (especially, natriuretic peptides) is discussed in the article. The most important evidences of clinical effectiveness of using biomarkers in patients with suspected heart failure and in patients with confirmed diagnose of heart failure are reviewed. The need to use natriuretic peptides in patients with takotsubo syndrome is discussed. Limited diagnostic value of using natriuretic peptides in renal dysfunction, as well as in other diseases in which the concentration of natriuretic peptides may increase in the absence of heart failure, is also discussed.
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Gilyarevskiy et al. (2017) conducted a review in Heart failure. Natriuretic peptides was evaluated. Natriuretic peptides are clinically effective for evaluating suspected and confirmed heart failure, though their diagnostic value is limited in renal dysfunction and other non-heart failure conditions.
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