Circulating renin-angiotensin-aldosterone system activity in cats with systemic hypertension or cardiomyopathy

Figures

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  FIGURE 1. Serum equilibrium concentrations and relationships of angiotensin peptides and aldosterone (RAAS fingerprints) in healthy cats (n = 34; A) compared to cats with systemic hypertension (n = 15; B) or cardiomyopathy (n = 17; C). Disease groups include both treated and untreated cats. Sizes of circles are proportional to the median concentration (pmol/L) of each analyte. Ang, angiotensin; Aldo, aldosterone; AT1R, angiotensin type 1 receptor

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  FIGURE 2. Box‐and‐whisker plots showing serum equilibrium concentrations of selected RAAS peptides by disease group in healthy cats (n = 34) compared to cats with systemic hypertension (n = 15) or cardiomyopathy (n = 17). Disease groups include both treated and untreated cats. Units for all RAAS biomarker concentrations are pmol/L. Boxes represent the interquartile range while the horizontal line in each box represents the group median, whiskers represent minimum and maximum values, and outliers (greater than 1.5 times the interquartile range above the 3rd quartile) are plotted as dots. P‐values for significant differences between groups are shown. ALD, aldosterone; Ang, angiotensin; CM, cardiomyopathy; PRA‐S, marker of plasma renin activity; SH, systemic hypertension

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  FIGURE 3. Serum equilibrium concentrations and relationships of angiotensin peptides and aldosterone (RAAS fingerprints) in healthy cats (n = 34; A) compared to cats with cardiomyopathy that were either not receiving furosemide treatment (n = 10; B) or furosemide‐treated (n = 7; C). Sizes of circles are proportional to the median concentration (pmol/L) of each analyte. Ang, angiotensin; Aldo, aldosterone; AT1R, angiotensin type 1 receptor

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  FIGURE 4. Box‐and‐whisker plots showing serum equilibrium concentrations of selected RAAS peptides by disease group in healthy cats (n = 34) compared to cats with cardiomyopathy not treated with furosemide (n = 10) and cats with cardiomyopathy treated with furosemide (n = 7). Units for all RAAS biomarker concentrations are pmol/L. Boxes represent the interquartile range while the horizontal line in each box represents the group median, minimum and maximum values, and outliers (greater than 1.5 times the interquartile range above the 3rd quartile), and outliers are plotted as dots. P‐values for significant differences between groups are shown. ALD, aldosterone; Ang, angiotensin; CM, cardiomyopathy; PRA‐S, marker of plasma renin activity

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  FIGURE 5. Serum equilibrium concentrations and relationships of angiotensin peptides and aldosterone (RAAS fingerprints) in healthy cats (n = 34) compared to cats with systemic hypertension that were either untreated (n = 8) or treated with amlodipine (n = 7). Sizes of circles are proportional to the median concentration (pmol/L) of each analyte. Ang, angiotensin; Aldo, aldosterone; AT1R, angiotensin type 1 receptor

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  FIGURE 6. Box‐and‐whisker plots showing serum equilibrium concentrations of selected RAAS peptides by disease group in healthy cats (n = 34) compared to cats with untreated systemic hypertension (n = 8) or systemic hypertension treated with amlodipine (n = 7). Units for all RAAS biomarker concentrations are pmol/L Boxes represent the interquartile range while the horizontal line in each box represents the group median, minimum and maximum values, and outliers (greater than 1.5 times the interquartile range above the 3rd quartile) are plotted as dots. P‐values for significant differences between groups are shown. ALD, aldosterone; Ang, angiotensin