What is the clinical evidence from this study?

Study design: Observational. Population: Healthy inactive young men (n=12). Intervention: Prolonged sitting vs. Baseline (pre-sitting). Primary outcome: Superficial femoral artery (SFA) and brachial artery (BA) flow-mediated dilation (FMD) (p=<0.001).

December 1, 2014Cardiovascular Ultrasound84 citationsOpen Access

Differences in brachial and femoral artery responses to prolonged sitting

Q: What are the key findings of this study?

Three hours of prolonged sitting resulted in a significant decline in superficial femoral artery flow-mediated dilation (p < 0.001) but not brachial artery flow-mediated dilation.

STSaurabh S. ThosarOregon Health & Science University SBSylvanna L. BielkoIndiana University Bloomington CWChad C. WigginsMayo Clinic

Key Result

Three hours of prolonged sitting resulted in a significant decline in superficial femoral artery flow-mediated dilation (p < 0.001) but not brachial artery flow-mediated dilation.

Study Design

Type

Observational (n=12)

Blinding

Single-blind

Multicenter

Structured PICO

Does 3 hours of prolonged sitting impair flow mediated dilation differently in the brachial and superficial femoral arteries in men?

Population

12 healthy, inactive young men (mean age 24.2 years) underwent a 3-hour prolonged sitting trial to evaluate limb-specific vascular responses.

Intervention

3 hours of prolonged sitting

Outcome

Superficial femoral artery (SFA) and brachial artery (BA) flow mediated dilation (FMD) and respective flow patterns measured at baseline, 1 hr, 2 hr and 3 hrsurrogate

Prolonged sitting for 3 hours impairs vascular function (FMD) in the lower extremities (femoral artery) but not the upper extremities (brachial artery).

Main Result

p-value: p=<0.001

Limitations

Did not measure blood pressure during the seated period.
Did not measure blood viscosity.
Did not measure muscle sympathetic nerve activity (MSNA).
Small sample size consisting only of young inactive men, limiting generalizability to women and other age groups.

Abstract

INTRODUCTION: It is unknown if there are limb differences in vascular function during prolonged sitting. PURPOSE: This study was designed to test whether the effects of prolonged sitting on brachial artery (BA) and the superficial femoral artery (SFA) are similar. METHODS: Twelve men (24.2 ± 4 yrs.) participated in a 3 hr prolonged sitting trial (SIT). SFA and BA flow mediated dilation (FMD) and respective flow patterns were measured at baseline, 1 hr, 2 hr and 3 hr. RESULTS: By a one-way ANOVA there was a significant decline in SFA FMD during 3 hrs of SIT (p < 0.001). Simultaneously, there was a significant decline in antegrade (p = 0.04) and mean (0.037) shear rates. By a one way ANOVA there were no significant differences in BA FMD during 3 hrs of sitting. There were no changes in the shear rates in the BA except for a significant decrease in antegrade shear rate (p = 0.029) and a significant increase in oscillatory shear index (p = 0.034) during 3 hrs of sitting. Furthermore, there was no correlation between BA and SFA FMD measurements. CONCLUSION: Three hours of sitting resulted in impaired SFA FMD but not BA FMD. Although 3 hours of sitting did not impair BA FMD, it impaired shear patterns in the BA.

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