Key result
Three hours of prolonged sitting resulted in a significant decline in superficial femoral artery flow-mediated dilation but not brachial artery flow-mediated dilation.
Why the study?
Does 3 hours of prolonged sitting impair flow mediated dilation differently in the brachial and superficial femoral arteries in men?
Observational (n=12)
Single-blind
No
Does 3 hours of prolonged sitting impair flow mediated dilation differently in the brachial and superficial femoral arteries in men?
Prolonged sitting for 3 hours impairs vascular function (FMD) in the lower extremities (femoral artery) but not the upper extremities (brachial artery).
Answers are grounded in this paper and cite their sources.
Prolonged sitting may impair lower- but not upper-limb endothelial function; hypothesis-generating for site-specific vascular effects.
INTRODUCTION: It is unknown if there are limb differences in vascular function during prolonged sitting. PURPOSE: This study was designed to test whether the effects of prolonged sitting on brachial artery (BA) and the superficial femoral artery (SFA) are similar. METHODS: Twelve men (24.2 ± 4 yrs.) participated in a 3 hr prolonged sitting trial (SIT). SFA and BA flow mediated dilation (FMD) and respective flow patterns were measured at baseline, 1 hr, 2 hr and 3 hr. RESULTS: By a one-way ANOVA there was a significant decline in SFA FMD during 3 hrs of SIT (p < 0.001). Simultaneously, there was a significant decline in antegrade (p = 0.04) and mean (0.037) shear rates. By a one way ANOVA there were no significant differences in BA FMD during 3 hrs of sitting. There were no changes in the shear rates in the BA except for a significant decrease in antegrade shear rate (p = 0.029) and a significant increase in oscillatory shear index (p = 0.034) during 3 hrs of sitting. Furthermore, there was no correlation between BA and SFA FMD measurements. CONCLUSION: Three hours of sitting resulted in impaired SFA FMD but not BA FMD. Although 3 hours of sitting did not impair BA FMD, it impaired shear patterns in the BA.
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Thosar et al. (2014) conducted an observational in Healthy inactive young men (n=12). Prolonged sitting vs. Baseline (pre-sitting) was evaluated on Superficial femoral artery (SFA) and brachial artery (BA) flow-mediated dilation (FMD) (p=<0.001). Three hours of prolonged sitting resulted in a significant decline in superficial femoral artery flow-mediated dilation but not brachial artery flow-mediated dilation.
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