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July 8, 2026Signal Transduction and Targeted TherapyOpen Access

Protein lactylation in health and diseases: molecular mechanisms, biological significance, and clinical implications

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Authors

YYYue YangYHYing HeZZZiyi Zhang

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Overview

Review demonstrates the role of protein lactylation in health and diseases, suggesting new biomarkers and therapies.

Key Points

  • This review aims to elucidate the role of protein lysine lactylation in biological processes and its implications in diseases.
  • Systematic review of the literature on protein lactylation in physiological and pathological contexts.
  • Analysis of molecular mechanisms involving lactylation enzymes and their effects on protein function and gene regulation.
  • Kla is crucial for gene expression, cell cycle, and signal transduction, impacting normal physiological processes.
  • Dysregulated Kla is linked to diseases such as cancer and cardiovascular disorders, affecting immune and metabolic functions.
  • Kla has potential as a biomarker and therapeutic target, offering new avenues for treatment strategies.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a4de7d8d2ea289ef6282cc1https://doi.org/10.1038/s41392-026-02757-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lactylation in concert with other post-translational modifications: Regulatory networks and disease implications2026
  2. 2Lysine lactylation in diseases: beyond histone lactylation2025
  3. 3Lysine lactylation in diseases: beyond histone lactylation2025
  4. 4The role of lactylation in age-related diseases: a molecular perspective2026 · 1 citations
  5. 5Lysine <scp>l</scp> ‐Lactylation: Bridging Metabolism, Chromatin and Disease2026