What question did this study set out to answer?

To compare physical function and evaluate neuromuscular changes in children with sickle cell disease during the 6MWT.

Neuromuscular Changes During the Six-Minute Walk Test in Pediatric Sickle Cell Disease

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Randomized trial evaluates neuromuscular changes during exercise in children with SCD, suggesting greater physiologic demands.

To compare physical function and evaluate neuromuscular changes in children with sickle cell disease during the 6MWT.
Conducted a 6-minute walk test (6MWT) with children having sickle cell disease.
Measured vastus lateralis muscle activity using surface electromyography and muscle oxygenation with Near-infrared spectroscopy.
Monitored heart rate continuously during the test.
Children with SCD covered less distance (482.7 ± 91.9 m) compared to norms (625.9 ± 55.1 m; p = 0.002).
Heart rate increased at each stage: start (121.3 ± 11.1 bpm), mid (139.0 ± 20.3 bpm; p = 0.009), end (142.1 ± 24.2 bpm; p = 0.009).
EMG median frequency significantly decreased throughout the 6MWT, indicating reduced neuromuscular function.

Marchese et al. (2026) studied this question.

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