Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 8, 2026Journal of Cutaneous Pathology

Elevated IL ‐4 and IL ‐13 Expression in Hailey‐Hailey Disease: Evidence for Th2‐Mediated Pathogenesis and Targeted Treatment

View Full Paper
Ask AI
Bookmark
Share

Authors

SGSimonetta I. GaumondVSVictoria SotoBABeatriz Abdo Abujamra

Discussion

Loading...

Member takes

Overview

Retrospective study shows elevated IL-4 and IL-13 in Hailey-Hailey disease, suggesting targeted treatments may be effective.

Key Points

  • The research aims to understand the role of IL-4 and IL-13 in the pathogenesis of Hailey-Hailey disease (HHD).
  • Retrospective analysis of skin samples from 7 patients with HHD, compared to 6 atopic dermatitis controls and 4 healthy controls.
  • Immunohistochemistry was used to assess IL-4 and IL-13 expression levels in skin lesions.
  • IL-4 was significantly higher in HHD epidermis (3966 cells/mm²) compared to negative control (808 cells/mm², p = 0.0219).
  • IL-13 was significantly elevated in the dermis of HHD (5288 cells/mm²) compared to healthy controls (629 cells/mm², p < 0.0001).
  • No significant differences were observed between AD and HHD samples.

Cite This Study

Gaumond et al. (2026) studied this question.

synapsesocial.com/papers/6a4de835d2ea289ef62830c0https://doi.org/10.1111/cup.70156
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Navigating Diagnostic Complexity in Hailey-Hailey Disease: A Case Report with Clinical-histopathological Correlation2025
  2. 2Neutrophilic Intraepidermal Pustular Dermatosis Mimicking Immunoglobulin A Pemphigus in a Patient with Hailey–Hailey Disease2026
  3. 3Exploring a Unique Case of Hailey-Hailey Disease: Understanding the Manifestation of Fragile Skin2024
  4. 4Dupilumab for Hailey-Hailey disease2025
  5. 5Atypical Follicular–Pigmentary Variant of Hailey–Hailey Disease: A Diagnostic Dilemma2026