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July 8, 2026ChannelsOpen Access

NOX2 drives oxidative stress to initiate and sustain AF and VA, highlighting a therapeutic target.

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Why the study?

The signaling pathways through which NOX2 modulates myocardial electrophysiology under different pathological states, and its dynamic coupling with upstream risk factors, remain unclear.

Design

Review

Key result

NOX2 mediates oxidative stress and plays a critical role in initiating and sustaining atrial fibrillation and ventricular arrhythmias, highlighting its potential as a therapeutic target.

Authors

BLBin LiYDYing DongYCYuehua Chen

Discussion

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Overview

NOX2 inhibition should not yet guide arrhythmia care; review extends mechanistic understanding while leaving clinical translation open.

Key Points

  • This review aims to explore the role of NADPH oxidase 2 in cardiac electrophysiological disorders, particularly its arrhythmogenic mechanisms.
  • Summarized the structure and activation mechanisms of NADPH oxidase 2.
  • Analyzed the impact of NOX2 on atrial fibrillation and ventricular arrhythmias.
  • Reviewed therapeutic strategies targeting NOX2 for arrhythmia management.
  • NOX2 is critically involved in calcium homeostasis disruption and ion channel regulation in cardiac tissue.
  • Therapeutic interventions targeting NOX2 show potential to mitigate cardiac arrhythmias.
  • The relationship between NOX2 and upstream risk factors, such as metabolic diseases, requires further investigation.

PICO

P
Population
Cardiac electrophysiological disorders and arrhythmias
E
Exposure / Comparator
NADPH oxidase 2 (NOX2)

NOX2 plays a critical role in initiating and sustaining atrial fibrillation and ventricular arrhythmias, making it a potential therapeutic target.

Limitations

  • The signaling pathways through which NOX2 modulates myocardial electrophysiology under different pathological states remain unclear.
  • The dynamic coupling of NOX2 with upstream risk factors, such as abnormal cardiac load and metabolic diseases, remains poorly characterized.

Cite This Study

Li et al. (2026) conducted a review in Cardiac electrophysiological disorders and arrhythmias. NADPH oxidase 2 (NOX2) was evaluated. NOX2 mediates oxidative stress and plays a critical role in initiating and sustaining atrial fibrillation and ventricular arrhythmias, highlighting its potential as a therapeutic target.

synapsesocial.com/papers/6a4de8a7d2ea289ef62833cbhttps://doi.org/10.1080/19336950.2026.2696810
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Dual Role of NOX4 in Cardiovascular Diseases: Driver of Oxidative Stress and Mediator of Adaptive Remodeling2025 · 15 citations
  2. 2Involvement of NADPH Oxidases in Cardiac Remodelling and Heart Failure2007 · 91 citations
  3. 3Loss of NOX2 (gp91<i>phox</i>) prevents oxidative stress and progression to advanced heart failure2014 · 57 citations
  4. 4Inducibility, but not stability, of atrial fibrillation is increased by NOX2 overexpression in mice2021 · 29 citations
  5. 5NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies2011 · 182 citations