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July 8, 2026Journal of Pediatric Gastroenterology and NutritionOpen Access

Heterogeneous outcomes in pediatric potential celiac disease: A multicenter longitudinal study

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Authors

BLBarak LaxerKaplan Medical CenterFRFiras RinawiTechnion – Israel Institute of TechnologyNZNadya Ziv‐SokolovskayaKaplan Medical Center

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Implication

Longitudinal study examines outcomes of children with potential celiac disease on gluten-containing diet, suggesting variable results.

Key Points

  • To investigate the outcomes of children with potential celiac disease consuming a gluten-containing diet over time.
  • Multicenter longitudinal follow-up of children with potential celiac disease diagnosed from December 2018 to January 2022.
  • Data collection included demographics, celiac serology, and biopsy results up to 39 months with a minimum follow-up of 12 months.
  • Patients diagnosed with celiac disease during follow-up were also monitored.
  • 19.5% of patients with potential celiac disease progressed to celiac disease over the follow-up period.
  • 37.5% of patients normalized anti-tissue transglutaminase antibodies while continuing a gluten-containing diet.
  • Asymptomatic patients had higher rates (61.9%) of tTG normalization compared to symptomatic ones (35.8%), p = 0.0011.

Cite This Study

Laxer et al. (2026) studied this question.

synapsesocial.com/papers/6a4de8a7d2ea289ef628351ahttps://doi.org/10.1002/jpn3.70501
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tissue transglutaminase levels above 100 U/mL and celiac disease: A prospective study2012 · 76 citations
  2. 2Prevalence and natural history of potential celiac disease in adult patients2013 · 75 citations
  3. 3The histopathology of coeliac disease1999 · 1,715 citations