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July 8, 2026npj Biological Physics and Mechanics.Open Access

Mechanics and engineering models of tissue remodelling during tumour progression

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Authors

JTJoshua ThiseltonPKPilnam Kim

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Overview

Review of mathematical models quantifying mechanical effects on cancer progression, hinting at new treatment avenues.

Key Points

  • This review aims to elucidate how mechanical stimuli influence tumour progression and the associated biological responses.
  • Reviewed mathematical models quantifying mechanical forces on cells and tissues.
  • Explored experiments measuring mechanical stress effects at various cancer stages.
  • Discussed the biological impacts of compression on cancer cells.
  • Identified significant roles of mechanical stimuli in tumour development.
  • Highlighted the importance of mechanical stress in different cancer stages.
  • Discussed potential therapeutic implications of compression in cancer treatment.

Cite This Study

Thiselton et al. (2026) studied this question.

synapsesocial.com/papers/6a4de8ebd2ea289ef6283619https://doi.org/10.1038/s44341-026-00041-x
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