Long-Term Cholecalciferol Supplementation and Metabolic Parameters in Postmenopausal Women with Type 2 Diabetes Mellitus: A Longitudinal Prospective Study
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Key Points
This study aims to assess the effects of long-term cholecalciferol supplementation on metabolic and cardiovascular parameters in postmenopausal women with type 2 diabetes mellitus.
Uncontrolled longitudinal prospective study design
34 postmenopausal women with type 2 diabetes received 1000 IU/day of cholecalciferol for 12 months followed by 2000 IU/day for another 12 months
Fasting blood tests and anthropometric assessments were conducted at baseline, 12 and 24 months.
Serum 25(OH)D levels and HDL-c increased significantly over the follow-up period.
Waist circumference and systolic blood pressure decreased across follow-up assessments.
Fasting blood glucose decreased from a median of 120 mg/dL at baseline to 110 mg/dL after supplementation, but differences were not statistically significant.
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Implication
Longitudinal prospective study evaluates metabolic improvements from cholecalciferol in postmenopausal women with T2DM, suggesting potential benefits.