What question did this study set out to answer?

This study aims to evaluate long-term axillary recurrence and overall survival among breast cancer patients with minimal sentinel node involvement, comparing groups based on axillary lymph node dissection.

July 8, 2026Annals of Surgical OncologyOpen Access

Axillary Recurrence and Survival After Omission of Axillary Lymph Node Dissection in Patients with Breast Cancer and Micrometastases or Isolated Tumor Cells in the Sentinel Node: A Danish National Register Study

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Authors

RKRiazan H.R. KorsholmGentofte Hospital NKNiels KromanGentofte Hospital TTTove F. TvedskovGentofte Hospital

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Implication

Retrospective study evaluates axillary recurrence and survival after omitting node dissection in breast cancer patients, suggesting continued de-escalation.

Key Points

This study aims to evaluate long-term axillary recurrence and overall survival among breast cancer patients with minimal sentinel node involvement, comparing groups based on axillary lymph node dissection.
Retrospective analysis of Danish Breast Cancer Group database from 2008 to 2021
Comparative analysis between patients undergoing axillary lymph node dissection before 2012 and those not undergoing it after guideline revision
Utilized Kaplan-Meier and multivariable Cox regression for survival analysis.
Axillary recurrence occurred in 1.1% of patients, with 1.5% in the no-ALND group compared to 0.2% in the ALND group, p < 0.001.
Long-term overall survival for pN1mi/pN0(i+) patients was 81.3% (95% CI 79.9-82.7), with no significant difference post-prognostic adjustment (p = 0.6).
Mastectomy-specific OS analysis showed no significant difference (p = 0.08).

Cite This Study

Korsholm et al. (2026) studied this question.

synapsesocial.com/papers/6a4de93fd2ea289ef62837cd https://doi.org/10.1245/s10434-026-20072-x

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Implication

Retrospective study evaluates axillary recurrence and survival after omitting node dissection in breast cancer patients, suggesting continued de-escalation.

Axillary Recurrence and Survival After Omission of Axillary Lymph Node Dissection in Patients with Breast Cancer and Micrometastases or Isolated Tumor Cells in the Sentinel Node: A Danish National Register Study

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Implication

Key Points

Cite This Study

Axillary Recurrence and Survival After Omission of Axillary Lymph Node Dissection in Patients with Breast Cancer and Micrometastases or Isolated Tumor Cells in the Sentinel Node: A Danish National Register Study

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Cite This Study

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