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July 8, 2026Scientific ReportsOpen Access

Serum miR-181a-5p, miR-214-3p, and miR-223-3p in epithelial ovarian cancer

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Authors

SBS. N. BaspinarIstanbul University-CerrahpaşaCKCanan KucukgerginIstanbul UniversityAAA. Fatih AydınIstanbul University

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Implication

Single-center case-control study evaluates serum microRNAs as potential biomarkers in ovarian cancer.

Key Points

  • This research aims to assess the expression levels of specific microRNAs in patients with epithelial ovarian cancer compared to healthy controls.
  • Single-center prospective case-control study involving 77 patients with histologically confirmed EOC and 74 healthy controls.
  • Quantified serum microRNA expression using quantitative real-time PCR with U6 RNA as an internal control.
  • Performed receiver operating characteristic (ROC) analysis to evaluate diagnostic performance.
  • Serum miR-181a-5p and miR-223-3p levels were significantly lower in EOC patients compared to controls (p < 0.001 for both).
  • No significant difference was observed for miR-214-3p (p = 0.505).
  • ROC analysis showed moderate diagnostic accuracy with AUC values of 0.704 for miR-181a-5p and 0.732 for miR-223-3p.

Cite This Study

Baspinar et al. (2026) studied this question.

synapsesocial.com/papers/6a4de976d2ea289ef6283a18https://doi.org/10.1038/s41598-026-60116-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Serum miR-181-5p, miR-214-3p, and miR-223-3p expression in epithelial ovarian cancer.2026
  2. 2Regulatory effects of miRNA in epithelial ovarian cancer patients: A case–control study from Eastern India2026
  3. 3Plasma exosomal miR-320d, miR-4479, and miR-6763-5p as diagnostic biomarkers in epithelial ovarian cancer2022 · 37 citations
  4. 4MicroRNA Signatures in Human Ovarian Cancer2007 · 1,425 citations
  5. 5Abstract B044: Serum miRNA expression in ovarian cancer patients is independent of histological subtype and FIGO stage2024