What question did this study set out to answer?

The review aims to address measurement issues surrounding neurocognitive impairment in HIV-associated conditions.

Measuring neurocognitive impairment in virally suppressed HIV: HIV-associated neurocognitive disorders, HIV-associated brain injury problems and solutions

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Review discusses neurocognitive impairment measurement in HIV, identifying challenges and potential solutions.

The review aims to address measurement issues surrounding neurocognitive impairment in HIV-associated conditions.
Analyzed existing criticisms of the HAND criteria and proposed terminology changes.
Discussed the impact of legacy and comorbidities on neurocognitive impairment.
Proposed potential solutions to improve the clinical utility of the HAND framework.
Criticisms of HAND highlight the exclusion of legacy effects and overestimation of neurocognitive impairment.
Evidence suggests low level HIV replication affects neurocognitive impairment despite viral suppression.
Resilience factors may mitigate the impact of persistent neurocognitive impairment in virally suppressed individuals.

Brew et al. (2026) studied this question.

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