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July 8, 2026Pancreas

Efficacy and Safety of Remimazolam versus Midazolam for Sedation during Endoscopic Ultrasound-Guided Tissue Acquisition in Patients with Solid Pancreatic Lesions

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Authors

YTYuki TanisakaSRS RyozawaMMMasafumi Mizuide

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Overview

Randomized trial compares the efficacy and safety of remimazolam and midazolam during tissue acquisition in patients with solid pancreatic lesions, indicating faster recovery with remimazolam.

Key Points

  • This research aims to compare the efficacy and safety of remimazolam versus midazolam for sedation during endoscopic ultrasound-guided tissue acquisition in patients with solid pancreatic lesions.
  • Retrospective review of 206 patients undergoing EUS-TA—101 with remimazolam and 105 with midazolam.
  • Primary outcome: time from procedure completion to patient awakening.
  • Secondary outcomes included sedation success rate, total dose, and sedation-related adverse events.
  • Median awakening time was shorter with remimazolam (2 min, IQR 2-3) compared to midazolam (4 min, IQR 3-5; P<0.01).
  • Higher median total doses were noted with remimazolam (P<0.01).
  • Flumazenil use was significantly lower with remimazolam (P<0.01), while other secondary outcomes did not show significant differences.

Cite This Study

Tanisaka et al. (2026) studied this question.

synapsesocial.com/papers/6a4de9add2ea289ef6283ca4https://doi.org/10.1097/mpa.0000000000002700
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy and Safety of Remimazolam Compared to Midazolam for Sedation During Endoscopic Ultrasonography: A Single‐Center Retrospective Cohort Study2026 · 4 citations
  2. 2Remimazolam Enables Faster Sedation Induction and Recovery Compared With Midazolam in Diagnostic Upper Gastrointestinal Endoscopy: A Multicenter Randomized Controlled Trial2025
  3. 3Remimazolam Enables Faster Sedation Induction and Recovery Compared With Midazolam in Diagnostic Upper Gastrointestinal Endoscopy: A Multicenter Randomized Controlled Trial2025 · 6 citations
  4. 4Comparison of Remimazolam and Midazolam for Sedation During Endoscopic Retrograde Cholangiopancreatography‐Related Procedures2026 · 2 citations
  5. 5Remimazolam vs. midazolam sedation in upper gastrointestinal endoscopy in adults ≥ 65 years: Randomized controlled trial2026 · 2 citations