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This research aims to create a comprehensive atlas of human peripheral immune cells by analyzing transcript isoforms and immune receptor sequences.

July 8, 2026Open Access

Single-Cell Multi-Omics Dissects Transcript Isoform and Immune Repertoire Dynamics in Human Immunosenescence-Raw Sequence Data

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Randomized trial examines immune repertoire and gene expression in young and elderly healthy donors, suggesting differences in senescence.

This research aims to create a comprehensive atlas of human peripheral immune cells by analyzing transcript isoforms and immune receptor sequences.
Utilized single-cell full-length transcriptome sequencing (scCycloneSEQ) and short-read scRNA-seq
Conducted single-cell TCR/BCR sequencing (scTCR/BCR-seq)
Profiled peripheral blood mononuclear cells (PBMCs) from both young and elderly healthy donors.
Identified distinctive transcript isoforms in the immune cells of elderly donors compared to younger ones
Revealed variations in the immune receptor sequences (TCR/BCR) between age groups
Demonstrated the complexity of immune dynamics associated with aging.

杨亚非(Yang yafei) (2026) studied this question.

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Randomized trial examines immune repertoire and gene expression in young and elderly healthy donors, suggesting differences in senescence.