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This research aims to explore the dynamics of immune repertoire and transcript isoforms in human immunosenescence.

July 8, 2026Open Access

Single-Cell Multi-Omics Dissects Transcript Isoform and Immune Repertoire Dynamics in Human Immunosenescence-Matrix

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Randomized trial investigates immune repertoire and transcript dynamics in healthy young and elderly individuals, suggesting insights into aging.

This research aims to explore the dynamics of immune repertoire and transcript isoforms in human immunosenescence.
Integrated single-cell multi-omics analysis including scCycloneSEQ and scTCR/BCR-seq.
Sampled peripheral blood mononuclear cells (PBMCs) from young and elderly healthy donors.
Profiled gene expression and transcript isoforms.
Characterized the transcript isoforms and immune receptor sequences in PBMCs across ages.
Revealed distinct immune dynamics between young and elderly donors.

杨亚非(Yang yafei) (2026) studied this question.

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Randomized trial investigates immune repertoire and transcript dynamics in healthy young and elderly individuals, suggesting insights into aging.