What question did this study set out to answer?

To explore the differential epigenetic profiles of macrophages and monocytes among various tissues using single-cell Multiome data.

November 1, 2025The Journal of ImmunologyOpen Access

Single-cell ATAC plus gene expression reveals differential epigenetic profiles of macrophages across tissue types 4001

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Single-cell Multiome reveals distinct gene expression and chromatin modifications in macrophages and monocytes across brain and other tissues.

To explore the differential epigenetic profiles of macrophages and monocytes among various tissues using single-cell Multiome data.
Utilized single-cell Multiome combining ATAC-seq and gene expression profiling.
Profiled cells from various tissues including brain and PBMC.
Compared epigenetic and gene expression data across species and tissue types.
Revealed unique chromatin landscapes for macrophages in different tissues.
Identified common features of immune cells across blood, brain, and cardiac tissues.
Showed the defining role of CSF1R in macrophage identity.

Garbati et al. (2025) studied this question.

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Single-cell Multiome reveals distinct gene expression and chromatin modifications in macrophages and monocytes across brain and other tissues.