Why the study?
An in-depth understanding of macrophage functions and characteristics is required in cardiovascular pathophysiology, but the classic M1/M2 paradigm is too limited to explain their heterogeneity and plasticity.
Design
Review
Authors
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Macrophage centrality in atherosclerosis, post-MI infiltration, and HF remodeling supports further study; leaves open targeted interventions.
Single-cell transcriptome sequencing provides valuable insights into the heterogeneity and plasticity of macrophages in cardiovascular diseases, advancing understanding of pathogenesis and potential treatments.
Li et al. (2023) studied this question.
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