What is the clinical evidence from this study?

Study design: Cohort. Population: Takotsubo syndrome (n=3152). Intervention: Smoking vs. Non-smokers. Primary outcome: All-cause fatality (long-term mortality) (p=0.97).

November 20, 2023Frontiers in Cardiovascular MedicineOpen Access

Smoking influence in Takotsubo syndrome: insights from an international cohort

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Key result

Smoking in Takotsubo syndrome is linked to longer hospital stays but not long-term mortality.

P=0.97
n=3,152

Why the study?

The influence of tobacco use on acute and long-term outcomes in Takotsubo syndrome was not well defined.

Does smoking influence acute and long-term outcomes in patients with Takotsubo syndrome?

Population

3,152 patients with Takotsubo syndrome

Comparison

Current smokers vs non-smokers

Design

International multicenter registry-based observational study with propensity score matching

Authors

INIván J. Núñez‐GilInterventional Cardiology FSFrancesco SantoroElectrophysiology RVRavi VaziraniHospital Clínico San Carlos

Discussion

Member takes

Implication

Anticipate longer stays among smokers with Takotsubo; leaves open any independent mortality effect.

Study Design

Type

Cohort (n=3,152)

Multicenter

Yes

Structured PICO

Does smoking influence acute and long-term outcomes in patients with Takotsubo syndrome?

Population

3,152 patients with Takotsubo syndrome from an international multicenter registry, followed to assess the impact of smoking on acute and long-term outcomes.

Exposure

Current smoking

Comparator

Non-smoking

Outcome

In-hospital complications, length of hospital stay, and long-term mortalityhard clinical

Main Result

Absolute Event Rate: 6.6% vs 7.2%

p-value: p=0.97

Limitations

Observational nature of the study prevents establishing cause-effect relationships.
Smoking habit status during follow-up or the amount of tobacco consumed were not available.
Potential country effect due to reporting differences, socioeconomic factors, or regional healthcare policies.

Cite This Study

Núñez‐Gil et al. (2023) conducted a cohort in Takotsubo syndrome (n=3,152). Smoking vs. Non-smokers was evaluated on All-cause fatality (long-term mortality) (p=0.97). Smoking in patients with Takotsubo syndrome was associated with longer in-hospital stays but did not independently impact long-term mortality compared to non-smokers.

synapsesocial.com/papers/6a4e2aafd923f1135ce0c875 https://doi.org/10.3389/fcvm.2023.1282018

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Smoking influence in Takotsubo syndrome: insights from an international cohort

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Smoking influence in Takotsubo syndrome: insights from an international cohort

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider