Key result
Single-pill combination of ARBs and CCBs was associated with greater odds of adherence (OR 1.90; 95% CI 1.75-2.08; p<0.001) compared to free-combination therapy.
Why the study?
Does single-pill combination of ARB and CCB improve adherence and persistence compared to free combination in patients newly initiated on antihypertensive therapy?
Population
4,525 adults newly initiated on angiotensin receptor blocker and calcium channel blocker treatment…
Comparison
Single-pill combination of angiotensin receptor… vs Free combination (multiple pills) of ARBs and CCBs
Design
Cohort
Follow-up
13 months
Authors
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Supports prioritizing single-pill combinations to reduce pill burden; extends prior adherence data but leaves open whether.
Cohort (n=4,525)
Yes
Does single-pill combination of ARB and CCB improve adherence and persistence compared to free combination in patients newly initiated on antihypertensive therapy?
Odds Ratio: 1.9 (95% CI 1.75–2.08)
p-value: p=< 0.001
Single-pill combination of ARB and CCB significantly improves medication adherence and persistence compared to free-combination regimens in patients initiating antihypertensive therapy.
Zeng et al. (2010) conducted a cohort in Hypertension (n=4,525). Single-pill combination of ARBs and CCBs vs. Free combination of ARBs and CCBs was evaluated on Adherence (proportion of days covered ≥ 0.80) (OR 1.90, 95% CI 1.75-2.08, p=< 0.001). Single-pill combination of ARBs and CCBs was associated with greater odds of adherence (OR 1.90; 95% CI 1.75-2.08; p<0.001) compared to free-combination therapy.
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