Key result
A single-pill fixed combination of perindopril, indapamide, and amlodipine achieved target blood pressure in 69.7% of patients with uncontrolled essential hypertension, compared to 50% in those taking the drugs as two separate pills.
Why the study?
Does a single-pill fixed-combination of perindopril/indapamide/amlodipine improve blood pressure control compared to a two-pill regimen in patients with uncontrolled essential hypertension?
RCT (n=12)
Randomly assigned
Yes
Does a single-pill fixed-combination of perindopril/indapamide/amlodipine improve blood pressure control compared to a two-pill regimen in patients with uncontrolled essential hypertension?
A single-pill triple-fixed combination of perindopril/amlodipine/indapamide effectively lowers blood pressure and may improve target achievement compared to a multi-pill regimen in patients with essential hypertension.
Hypertension is the major risk factor in Serbia and worldwide for the morbidity and mortality from cardiovascular and cerebrovascular diseases. A majority of patients need two or more antihypertensive drugs to adequately control blood pressure. Our study group consisted of 12 patients with uncontrolled essential hypertension, without comorbidities, divided in two groups and followed for 12 weeks. The first group was treated with a single-pill of fixed-combination Perindopril 5 mg/Indapamide 1.25 mg and an additional tablet of Amlodipine 5 mg. The second group received a single-pill fixed-combination of Perindopril 5 mg/Indapamide 1.25 mg/Amlodipine 5 mg. Our research showed significant decreases in systolic (p=0,05) and diastolic (p<0,05) blood pressure in both groups after 12 weeks of treatment. The study also showed a higher percentage of patients who achieved the targeted blood pressure (< 140/90 mmHg) on the single-pill triple combination drug (69.7%) in comparison with the other group (50%). No adverse effects were recorded in both groups. Our results revealed significant efficacy and tolerability of a single-pill triple-fixed combination Perindopril/Amlodipine/ Indapamide in patients with uncontrolled essential hypertension without comorbidities.
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Tasić et al. (2016) conducted an RCT in Essential hypertension (n=12). Single-pill fixed combination of Perindopril/Indapamide/Amlodipine vs. Perindopril 5 mg / Indapamide 1.25 mg as one pill and Amlodipine 5 mg as a separate drug was evaluated on Achievement of target blood pressure (<140/90 mmHg). A single-pill fixed combination of perindopril, indapamide, and amlodipine achieved target blood pressure in 69.7% of patients with uncontrolled essential hypertension, compared to 50% in those taking the drugs as two separate pills.
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