Key result
Platelet function assays show poor agreement, yielding aspirin resistance prevalence estimates up to ~60%.
Why the study?
The study compared results from six major platelet function tests to assess the prevalence of aspirin resistance in patients with stable coronary artery disease.
Do different platelet function tests yield consistent results in determining the prevalence of aspirin resistance in patients with stable coronary artery disease?
Population
201 patients with stable coronary artery disease receiving daily aspirin therapy (>=80 mg)
Comparison
Six major platelet function tests
Authors
Loading...
Variable aspirin resistance rates and poor assay agreement caution against clinical reliance; leaves open need for standardized tests in stable CAD.
Cross-Sectional (n=201)
Do different platelet function tests yield consistent results in determining the prevalence of aspirin resistance in patients with stable coronary artery disease?
Different platelet function tests yield highly variable rates of aspirin resistance and correlate poorly with each other, questioning their clinical utility for this purpose.
Lordkipanidzé et al. (2007) conducted a cross-sectional in stable coronary artery disease (n=201). Six major platelet function tests was evaluated on Prevalence of aspirin resistance. The prevalence of aspirin resistance varied widely from 4% to 59.5% depending on the platelet function test used, with poor correlation and agreement among the six assays.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: