Key result
Increasing age in asymptomatic adults decreased the odds of an S3 (OR 0.96) and increased the odds of an S4 (OR 1.04), with overall prevalences of 10.0% and 15.6% respectively.
Cross-Sectional (n=1,329)
Odds Ratio: 1.04 (95% CI 1.03–1.05)
In asymptomatic adults, S3 is more common in younger individuals while S4 prevalence increases with age, though S4 is less common overall than previously thought, suggesting its detection should not be ignored even in the elderly.
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Prevalence of electronically detected S3/S4 in asymptomatic adults leaves open their clinical utility; longitudinal studies needed to clarify prognostic value.
Collins et al. (2005) conducted a cross-sectional in Asymptomatic adults (n=1,329). Increasing age was evaluated on Detection of S4 (OR 1.04, 95% CI 1.03-1.05). Increasing age in asymptomatic adults decreased the odds of an S3 (OR 0.96) and increased the odds of an S4 (OR 1.04), with overall prevalences of 10.0% and 15.6% respectively.
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