Key result
Macrophages play diverse roles in maintaining cardiovascular homeostasis, and an imbalance in these mechanisms contributes to the development of cardiovascular disease.
Why the study?
Macrophages play diverse roles in cardiovascular homeostasis and disease development, highlighting a need to clarify their mechanisms to identify preventative, diagnostic, and therapeutic strategies for patients with CVD.
This review emphasizes the critical role of macrophages in cardiovascular homeostasis and disease, suggesting them as potential targets for preventative, diagnostic, and therapeutic strategies.
Macrophage imbalance drives CVD; leaves open targeted immunomodulation as a clinical strategy.
Cardiovascular disease (CVD) is one of the greatest public health concerns and is the leading cause of morbidity and mortality in the United States and worldwide. CVD is a broad yet complex term referring to numerous heart and vascular conditions, all with varying pathologies. Macrophages are one of the key factors in the development of these conditions. Macrophages play diverse roles in the maintenance of cardiovascular homeostasis, and an imbalance of these mechanisms contributes to the development of CVD. In the current review, we provide an in-depth analysis of the diversity of macrophages, their roles in maintaining tissue homeostasis within the heart and vasculature, and the mechanisms through which imbalances in homeostasis may lead to CVD. Through this review, we aim to highlight the potential importance of macrophages in the identification of preventative, diagnostic, and therapeutic strategies for patients with CVD.
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Stevens et al. (2022) conducted a review in Cardiovascular disease. Macrophages was evaluated. Macrophages play diverse roles in maintaining cardiovascular homeostasis, and an imbalance in these mechanisms contributes to the development of cardiovascular disease.
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