Key result
Genetic lineage tracing in mouse models showed no evidence of epithelial-to-mesenchymal transition during adult valve homeostasis or pathogenesis, but increased immune cells may contribute to MVD.
Contrary to previous in vitro studies, in vivo genetic lineage tracing demonstrates that epithelial-to-mesenchymal transition does not occur in adult valve homeostasis or myxomatous valve disease.
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Challenges in vitro EMT hypotheses in valve disease; leaves open immune cell roles in MVD pending human validation.
Kim et al. (2018) studied Myxomatous valve disease. Genetic lineage tracing was evaluated on Evidence of epithelial-to-mesenchymal transition (EMT). Genetic lineage tracing in mouse models showed no evidence of epithelial-to-mesenchymal transition during adult valve homeostasis or pathogenesis, but increased immune cells may contribute to MVD.
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