Key result
Abdominal obesity in normotensive healthy subjects was associated with a higher cardiac remodeling index (0.67 vs 0.60 g/mL; P=0.026) and increased prevalence of diastolic dysfunction (38% vs 4%).
Why the study?
Does abdominal obesity associate with early changes in cardiac structure, function, and fibrosis biomarkers in normotensive healthy subjects?
Population
140 normotensive healthy subjects (87 with abdominal obesity and 53 age- and sex-matched controls)
Comparison
Abdominal obesity vs Age- and sex-matched controls without abdominal…
Design
Cross-sectional
Authors
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Suggests early cardiac effects of abdominal obesity despite normal BP; hypothesis-generating and requires longitudinal confirmation before clinical relevance.
Case-Control (n=140)
Does abdominal obesity associate with early changes in cardiac structure, function, and fibrosis biomarkers in normotensive healthy subjects?
Absolute Event Rate: 0.67% vs 0.6%
p-value: p=0.026
Normotensive healthy subjects with abdominal obesity exhibit early signs of cardiac structural remodeling, fibrosis, and diastolic dysfunction, which are independently associated with higher blood pressure and procollagen-III-N-terminal peptide levels.
Eschalier et al. (2014) conducted a case-control in Abdominal obesity (n=140). Abdominal obesity vs. Age- and sex-matched controls without abdominal obesity was evaluated on Cardiac remodeling index (p=0.026). Abdominal obesity in normotensive healthy subjects was associated with a higher cardiac remodeling index (0.67 vs 0.60 g/mL; P=0.026) and increased prevalence of diastolic dysfunction (38% vs 4%).
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