Key result
Ultra-low dose landiolol significantly reduced the incidence of atrial fibrillation in the first postoperative week to 4.8% compared to 27% with diltiazem after off-pump CABG.
Why the study?
Does ultra-low dose landiolol prevent postoperative atrial fibrillation in patients undergoing off-pump CABG compared to diltiazem?
Population
47 patients who underwent isolated off-pump coronary artery bypass grafting (CABG)
Comparison
Ultra-low dose landiolol hydrochloride… vs Diltiazem hydrochloride administered from ICU…
Design
RCT, Randomly divided
Follow-up
1 week
Authors
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May support ultra-low dose landiolol for post-CABG AF prevention; hypothesis-generating in a small cohort and requires RCT confirmation.
RCT (n=47)
Single-blind
Computer-generated table
No
Does ultra-low dose landiolol prevent postoperative atrial fibrillation in patients undergoing off-pump CABG compared to diltiazem?
Absolute Event Rate: 4.8% vs 27%
p-value: p=0.046
Ultra-low dose landiolol is effective for preventing postoperative atrial fibrillation after off-pump CABG compared to diltiazem, without worsening hemodynamics.
Nagaoka et al. (2013) conducted an RCT in Postoperative atrial fibrillation (n=47). Landiolol hydrochloride vs. Diltiazem hydrochloride was evaluated on Incidence of atrial fibrillation within one week after surgery (p=0.046). Ultra-low dose landiolol significantly reduced the incidence of atrial fibrillation in the first postoperative week to 4.8% compared to 27% with diltiazem after off-pump CABG.
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