Randomized trial investigates clinical effects of N-acetylcysteine on liver injury in dengue, suggesting future guidelines.
Dengue-associated liver injury is common, prognostically significant, and associated with high mortality at severe thresholds. Oxidative stress is a key, potentially modifiable mechanism. N-acetylcysteine has strong biological plausibility and supportive preclinical data, but clinical evidence remains limited, underscoring the need for well-designed randomised trials to inform practice and policy.
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McBride et al. (2026) studied this question.
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