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This report demonstrates an iron-catalyzed fluorosulfonylation method for carboxylic acids, suggesting a new way to modify drugs and natural compounds.
In this report, we describe an LMCT-based iron-catalyzed strategy for the decarboxylative fluorosulfonylation of aliphatic carboxylic acids, using DABSO as the SO 2 source and NFSI as the fluorine reagent. The Fe(III)/Fe(II) redox cycle enables simultaneous activation of the carboxylic acid and reduction of the sulfonyl radical. This strategy efficiently generates sulfonyl fluorides under mild conditions and facilitates late-stage functionalization of drugs, natural products, and peptides.
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Zhao et al. (2026) studied this question.
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