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July 7, 2026NutrientsOpen Access

Structural Characteristics and Gut Microbiota-Mediated Immunomodulatory Mechanisms of Water- and Alkali-Extracted Polysaccharides from Tuber indicum

Hongfei Ji Hongfei Ji Mei Li Dewen Mao Yuehua Chen Bing Han Yanli Zheng Wenjie Ding Haiyu Ji Haiyu Ji

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Key Points

The aim is to characterize the structural features and immunoregulatory mechanisms of polysaccharides from Tuber indicum.
Polysaccharide fractions (TIWP and TIAP) were prepared and structurally characterized.
In vivo bioactivity evaluation was performed, focusing on immune cell proportions and tissue damage.
Untargeted metabolomics and KEGG pathway analysis were conducted to elucidate the metabolic pathways involved.
TIWP has a molecular weight of 2.65 × 10^7 Da, while TIAP has a higher molecular weight of 3.87 × 10^7 Da.
Both TIWP and TIAP significantly restored CD3+ T and CD19+ B cell proportions, alleviating tissue damage.
TIWP enriched Lactobacillus and Ruminiclostridium, while TIAP increased Lactobacillus and Alloprevotella abundances.

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Implication

Demonstrates immunomodulatory effects of polysaccharides in Tuber indicum, suggesting potential for functional foods.

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Cite This Study

Ji et al. (2026) studied this question.

synapsesocial.com/papers/6a4f3c252b81a944af575bf6 https://doi.org/10.3390/nu18132202

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